The future advancements in the management of erectile dysfunction goes back to the DNA – we have gene therapy. Here, the penis is particularly well suited amongst the list of its possibilities. Because the penis is external and easily accessible, a tourniquet can be readily applied (for up to 10 minutes) to prevent any injected genes from entering the rest of the body. Moreover, vascular smooth muscle cells, the probable targets for many gene therapies, have a low turnover rate, increasing the chances for the effects of the therapy to last for weeks or months. Gene therapy can be used in different ways, including the insertion of genes into penile Sildenafil citrate online Australia cells to produce proteins that are lacking because of missing or defective genes. Injected DNA could also generate proteins that would make the penis more sensitive to compensate for an organic disorder.
A couple of therapy approaches are currently being studied for efficacy. Jacob Rajfer of the University of California at Los Angeles Medical Center is attempting to introduce a precursor gene into the penis to boost nitric oxide production when the gene is activated by a chemical stimulant or irritant. My own lab is investigating the efficacy of inserting a gene subunit that would allow potassium ions to move freely out of the cells of the corpora cavernosa. This change would increase the relaxation of the smooth muscle cells and make the penis extremely sensitive to stimulation. In studies on rats, the inserted DNA remained active for at least four months. The penises of diabetic and aged rats receiving the gene responded to stimuli in the same manner as the organs of young or healthy rats did. There have been no adverse effects on the hundreds of rats tested. The potential for a safe, sustained therapy in humans that would allow spontaneous erections is truly encouraging and will be brought to clinical testing in the near future.
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The Psychological Aspect of Impotence
If you have no organic cause for impotence – say you didn’t have a paralyzing back injury, diabetes, taking some antihypertensive drugs, etc., most likely, the cause of your erectile dysfunction is psychological. This is almost all true to young males. So let us see the common psychological causes of impotence:
- Stress: Is number one on the list. Stress can be job-related, moneyrelated, or the result of marital problems, among other factors.
- Low self-esteem: This can be due to prior episodes of impotence (thus a feeling of inadequacy) or can be the result of other issues unrelated to sexual performance.
- Guilt: A man may feel guilty that he is not satisfying his partner.
- Anxiety: Once a man experiences impotence, he may become overly worried that the problem will happen again. This can lead to “performance anxiety,” or a fear of sexual failure, and consistently cause impotence.
- Depression: Depression and anxiety can be both the cause and the consequence of impotence. Depression affects a person physically and psychologically.
- Fatigue: Fatigue drains mental and physical energy and can result in anxiety if the problem is not addressed. Like stress, once fatigue is reduced, normal sexuality is restored.
- Drugs used to treat depression may also cause impotence and may also interfere with the effectiveness of the popular impotence pills, such as Viagra.